BDBM369165 4-methyl-N-[4-(5-methyl-7H-pyrrolo[2,3- d]pyrimidin-4- yl)phenyl]benzenesulfonamide::US10227357, Compound P-0448

SMILES Cc1c[nH]c2ncnc(-c3ccc(NS(=O)(=O)c4ccc(C)cc4)cc3)c12

InChI Key InChIKey=AZGYEGKAMUPHHW-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369165   

LigandPNGBDBM369165(US10227357, Compound P-0448 | 4-methyl-N-[4-(5-met...)
Affinity DataKi:  500nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Plexxikon

US Patent
LigandPNGBDBM369165(US10227357, Compound P-0448 | 4-methyl-N-[4-(5-met...)
Affinity DataKi:  5.50E+3nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent