BDBM370454 1-cyclopentyl-2-(5H-imidazo[5,1-a]isoindol-5- yl)ethanol::US10233190, Example 1362

SMILES OC(CC1c2ccccc2-c2cncn12)C1CCCC1

InChI Key InChIKey=MTNKITWGIJLVJD-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 370454   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

US Patent
LigandPNGBDBM370454(1-cyclopentyl-2-(5H-imidazo[5,1-a]isoindol-5- yl)e...)
Affinity DataIC50: 1.00E+3nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

US Patent
LigandPNGBDBM370454(1-cyclopentyl-2-(5H-imidazo[5,1-a]isoindol-5- yl)e...)
Affinity DataIC50: 160nMAssay Description:Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

US Patent
LigandPNGBDBM370454(1-cyclopentyl-2-(5H-imidazo[5,1-a]isoindol-5- yl)e...)
Affinity DataEC50:  780nMAssay Description:Inhibition of recombinant human IDO1 expressed in T-REx-293 cells assessed as reduction in kynurenine level measured after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed