BDBM371204 4-(Cyclopropanecarbonyl)-N-(1-methylcyclopropyl)-2-[(3-methylisoxazol-5-yl)methyl]-1-oxo-isoquinoline-7-sulfonamide::US10239843, Example 311

SMILES Cc1cc(Cn2cc(C(=O)C3CC3)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)on1

InChI Key InChIKey=IDFPLLUXTURGIG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 371204   

TargetPoly(ADP-ribose) glycohydrolase(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 371204BDBM371204(US10239843, Example 311 | 4-(Cyclopropanecarbonyl)...)
Affinity DataIC50: 549nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 371204BDBM371204(US10239843, Example 311 | 4-(Cyclopropanecarbonyl)...)
Affinity DataIC50: 1.50E+5nMAssay Description:PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetADP-ribosylhydrolase ARH3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 371204BDBM371204(US10239843, Example 311 | 4-(Cyclopropanecarbonyl)...)
Affinity DataIC50: 1.50E+5nMAssay Description:ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent