BDBM373085 1-(1,3-diphenyl-1H- pyrazol-5-yl)-3- pyridin-2-ylurea::US9896447, Compound 2

SMILES O=C(Nc1cc(nn1-c1ccccc1)-c1ccccc1)Nc1ccccn1

InChI Key InChIKey=HZTBFXKWQIQMLW-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373085   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM373085(1-(1,3-diphenyl-1H- pyrazol-5-yl)-3- pyridin-2-ylu...)
Affinity DataIC50: 160nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells are express TrkA receptor as a fusion with the we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent