BDBM374735 US10246467, Example I-6::US10919913, # I-6::US20240109913, Example I-6

SMILES OC(=O)c1ccc2nn3[C@H]4[C@@H](COc3c2c1)N(CC1CC1)[C@@]1([C@@H]4c2cccc(Cl)c2F)C(=O)Nc2cc(Cl)ccc12

InChI Key InChIKey=JJCQXIRROLOGAC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 374735   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 374735BDBM374735(US10246467, Example I-6 | US10919913, # I-6 | US20...)
Affinity DataIC50: 619nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent

TargetCellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 374735BDBM374735(US10246467, Example I-6 | US10919913, # I-6 | US20...)
Affinity DataIC50: 619nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 374735BDBM374735(US10246467, Example I-6 | US10919913, # I-6 | US20...)
Affinity DataIC50: 619nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent