BDBM374744 US10246467, Example I-15::US10919913, # I-15::US20240109913, Example I-15

SMILES CS(=O)(=O)c1ccc2c3OC[C@@H]4[C@@H]([C@@H](c5cccc(Cl)c5F)[C@]5(N4CC4CC4)C(=O)Nc4cc(Cl)ccc54)n3nc2c1

InChI Key InChIKey=VDSFSAYTPKMMRH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 374744   

TargetCellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374744(US10246467, Example I-15 | US10919913, # I-15 | US...)
Affinity DataIC50: 261nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374744(US10246467, Example I-15 | US10919913, # I-15 | US...)
Affinity DataIC50: 261nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
Go to US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374744(US10246467, Example I-15 | US10919913, # I-15 | US...)
Affinity DataIC50: 261nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
Go to US Patent