BDBM374772 US10246467, Example I-69::US10919913, # I-69::US20240109913, Example I-69

SMILES CCOc1cccc(CN2[C@@H]3COc4n(nc5cc(ccc45)C(O)=O)[C@@H]3[C@@H](c3cccc(Cl)c3F)[C@@]22C(=O)Nc3cc(Cl)ccc23)c1

InChI Key InChIKey=ATDZTLRGKQSJFT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 374772   

TargetCellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 374772BDBM374772(US10246467, Example I-69 | US10919913, # I-69 | US...)
Affinity DataIC50: 2.14E+3nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 374772BDBM374772(US10246467, Example I-69 | US10919913, # I-69 | US...)
Affinity DataIC50: 2.14E+3nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Boehringer Ingelheim International

US Patent
LigandChemical structure of BindingDB Monomer ID 374772BDBM374772(US10246467, Example I-69 | US10919913, # I-69 | US...)
Affinity DataIC50: 2.14E+3nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent