BDBM375420 US10358436, Example A133::US9907800, Example A132::US9907800, Example A133

SMILES COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4cccc(CN5CCOCC5)c4)n[nH]c3c1)C(=O)N2

InChI Key InChIKey=PXWPZSUQVIGWMZ-UHFFFAOYSA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 375420   

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase PLK4(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase PLK4(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 100nMAssay Description:The enzymatic activity of FLT3 was determined using the Z-Lyte assay kit from Invitrogen (Invitrogen cat #PV3191). The assay was performed using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 100nMAssay Description:PLK3 inhibition was determined using the Z-Lyte assay kit from Invitrogen (cat #PV3802). The assay was performed using the recommended manufacturer&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase A(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase A(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 550nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetAurora kinase A(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 375420BDBM375420(US9907800, Example A132 | US9907800, Example A133 ...)
Affinity DataIC50: 550nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent