BDBM377478 4-(1-acryloyl-1-azaspiro[4.4] nonan-7-yl)-3-fluoro-7- (trifluoromethyl)-9H- carbazole-1-carboxamide::US10266491, Example 171::US10676434, Example 171::US11053197, Example 171

SMILES NC(=O)c1cc(F)c(C2CCC3(CCCN3C(=O)C=C)C2)c2c3ccc(cc3[nH]c12)C(F)(F)F

InChI Key InChIKey=UUQHGVLKHQRAHF-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 377478   

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM377478(US10266491, Example 171 | 4-(1-acryloyl-1-azaspiro...)
Affinity DataIC50: 6nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM377478(US10266491, Example 171 | 4-(1-acryloyl-1-azaspiro...)
Affinity DataIC50: 6nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 μM), A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM377478(US10266491, Example 171 | 4-(1-acryloyl-1-azaspiro...)
Affinity DataIC50: 6nMAssay Description:To V-bottom 384-well plates were added test compounds, human recombinant Btk (1 nM, Invitrogen Corporation), fluoresceinated peptide (1.5 ATP (20 and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/6/2022
Entry Details
US Patent