BDBM377713 5-amino-1-(1-cyanopyrrolidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-4-carboxamide::US10266513, Example 7::US10815213, Example 7

SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C#N

InChI Key InChIKey=CKEDNEKCKJKNNJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377713   

TargetTyrosine-protein kinase BTK(Human)
Pfizer

US Patent
LigandPNGBDBM377713(US10266513, Example 7 | 5-amino-1-(1-cyanopyrrolid...)
Affinity DataIC50: 16.2nMAssay Description:TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide peptid...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Pfizer

US Patent
LigandPNGBDBM377713(US10266513, Example 7 | 5-amino-1-(1-cyanopyrrolid...)
Affinity DataIC50: 16.2nMAssay Description:BTK: TR-FRET LanthaScreen assays were performed by incubating a dilution series of inhibitor concentrations with 50 μM ATP, 100 nM FAM-Srctide p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent