BDBM378049 N-(((R)-1-(D-alanyl)pyrrolidin-3-yl)methyl)-2-oxoindoline-5-carboxamide::US10266526, Compound 177

SMILES C[C@@H](N)C(=O)N1CC[C@H](CNC(=O)c2ccc3NC(=O)Cc3c2)C1

InChI Key InChIKey=CKWKXVSGFZLSFL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378049   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM378049(N-(((R)-1-(D-alanyl)pyrrolidin-3-yl)methyl)-2-oxoi...)
Affinity DataIC50: 1.98E+4nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent