BDBM378359 N-(1-(1-(L-alanyl)piperidin-4-yl)ethyl)-6-chloro-2-oxoindoline-5-carboxamide::US10266526, Compound 490

SMILES C[C@H](N)C(=O)N1CCC(CC1)C(C)NC(=O)c1cc2CC(=O)Nc2cc1Cl

InChI Key InChIKey=LOMVGSGLUXBGLH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378359   

TargetHistone-lysine N-methyltransferase SMYD3(Human)
Epizyme

US Patent
LigandPNGBDBM378359(N-(1-(1-(L-alanyl)piperidin-4-yl)ethyl)-6-chloro-2...)
Affinity DataIC50: 430nMAssay Description:The assays were all performed in a buffer consisting of 25 mM Tris-Cl pH 8.0, 1 mM TCEP, 0.005% BSG, and 0.005% Tween 20, prepared on the day of use....More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent