BDBM380621 (R)-6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-2-(6-methoxypyridin-3-yl)-3-methyl-5,6-dihydropyrrolo[3,4-d]imidazol-4(3H)-one::US9890166, Example 7

SMILES COc1ccc(cn1)-c1nc2[C@H](N(C(=O)c2n1C)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1

InChI Key InChIKey=MZKIOOQWOZDDMX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380621   

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380621BDBM380621(US9890166, Example 7 | (R)-6-(4-chlorophenyl)-5-(1...)
Affinity DataIC50: 48nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380621BDBM380621(US9890166, Example 7 | (R)-6-(4-chlorophenyl)-5-(1...)
Affinity DataIC50: 56nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380621BDBM380621(US9890166, Example 7 | (R)-6-(4-chlorophenyl)-5-(1...)
Affinity DataIC50: 60nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380621BDBM380621(US9890166, Example 7 | (R)-6-(4-chlorophenyl)-5-(1...)
Affinity DataIC50: 1.50E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent