BDBM380653 (R)-6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)-3-ethyl-2-(6-methoxypyridin-3-yl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(3H)-one::US9890166, Example 39

SMILES CCn1c(nc2[C@H](N(C(=O)c12)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1)-c1ccc(OC)nc1

InChI Key InChIKey=FQEWVABJRCOJBI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380653   

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380653BDBM380653(US9890166, Example 39 | (R)-6-(4-chlorophenyl)-5-(...)
Affinity DataIC50: 24nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380653BDBM380653(US9890166, Example 39 | (R)-6-(4-chlorophenyl)-5-(...)
Affinity DataIC50: 28.5nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380653BDBM380653(US9890166, Example 39 | (R)-6-(4-chlorophenyl)-5-(...)
Affinity DataIC50: 32nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380653BDBM380653(US9890166, Example 39 | (R)-6-(4-chlorophenyl)-5-(...)
Affinity DataIC50: 910nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent