BDBM380666 6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-yl)-1-isopropyl-5-(8-methoxy-3-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one::US9890166, Example 53

SMILES COc1cc(cn2c(C)nnc12)N1C(c2c(nc(C3=CCOCC3)n2C(C)C)C1=O)c1ccc(Cl)cc1

InChI Key InChIKey=NTQVJGUGYLGXNI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380666   

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380666BDBM380666(US9890166, Example 53 | 6-(4-chlorophenyl)-2-(3,6-...)
Affinity DataIC50: 92nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380666BDBM380666(US9890166, Example 53 | 6-(4-chlorophenyl)-2-(3,6-...)
Affinity DataIC50: 200nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380666BDBM380666(US9890166, Example 53 | 6-(4-chlorophenyl)-2-(3,6-...)
Affinity DataIC50: 220nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380666BDBM380666(US9890166, Example 53 | 6-(4-chlorophenyl)-2-(3,6-...)
Affinity DataIC50: 3.70E+4nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent