BDBM380698 (R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-isopropyl-2-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H-one::US9890166, Example 85

SMILES Cc1cc(N2C(=O)c3nc(C4=CCCN(C)C4)n(C(C)C)c3[C@H]2c2ccc(Cl)cc2)cn2c(C)nnc12

InChI Key InChIKey=GLMGIYSAZNFOHX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380698   

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380698BDBM380698((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Affinity DataIC50: 15nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380698BDBM380698((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Affinity DataIC50: 20nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380698BDBM380698((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Affinity DataIC50: 29nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380698BDBM380698((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Affinity DataIC50: 3.65E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent