BDBM380721 (R)-6-(4-chlorophenyl)-1-isopropyl-5-((4-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-6-yl)-2-(tetrahydro-2H-pyran-4-yl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one::US9890166, Example 108

SMILES COc1cc(cc2n(C)nnc12)N1[C@@H](c2c(nc(C3CCOCC3)n2C(C)C)C1=O)c1ccc(Cl)cc1

InChI Key InChIKey=AREGGTVPTLNTCU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380721   

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380721BDBM380721((R)-6-(4-chlorophenyl)-1-isopropyl-5-((4-methoxy-1...)
Affinity DataIC50: 61nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380721BDBM380721((R)-6-(4-chlorophenyl)-1-isopropyl-5-((4-methoxy-1...)
Affinity DataIC50: 74nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380721BDBM380721((R)-6-(4-chlorophenyl)-1-isopropyl-5-((4-methoxy-1...)
Affinity DataIC50: 180nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380721BDBM380721((R)-6-(4-chlorophenyl)-1-isopropyl-5-((4-methoxy-1...)
Affinity DataIC50: 9.75E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent