BDBM380748 6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2-(2-methoxy-4-(trifluoromethyl)phenyl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one::US9890166, Example 136

SMILES COc1cc(C(F)(F)F)ccc1-c1nc2c([nH]1)C(c1ccc(Cl)cc1)N(c1cc(C)c3nnc(C)n3c1)C2=O

InChI Key InChIKey=PHSQIKIQGFDDEU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 380748   

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380748BDBM380748(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Affinity DataIC50: 30nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380748BDBM380748(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Affinity DataIC50: 32nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380748BDBM380748(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Affinity DataIC50: 2.60E+3nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent