BDBM380753 6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-2-(6-methoxypyridin-3-yl)-5,6-dihydropyrrolo[3,4-d]imidazol-4(1H)-one::US9890166, Example 141

SMILES COc1ccc(-c2nc3c([nH]2)C(c2ccc(Cl)cc2)N(c2cc(C)c4nnc(C(F)F)n4c2)C3=O)cn1

InChI Key InChIKey=GAFAVXVVQUWUQX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 380753   

TargetBromodomain-containing protein 3(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380753BDBM380753(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-...)
Affinity DataIC50: 21nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 4(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380753BDBM380753(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-...)
Affinity DataIC50: 23.5nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetBromodomain-containing protein 2(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380753BDBM380753(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-...)
Affinity DataIC50: 47nMAssay Description:All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent

TargetCREB-binding protein(Human)
Novartis

US Patent
LigandChemical structure of BindingDB Monomer ID 380753BDBM380753(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-...)
Affinity DataIC50: 3.70E+4nMAssay Description:In order to assess bromodomain selectivity, we set up a binding assay using the bromodomain encoded by the CREBBP gene. Compounds were tested in the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
US Patent