BDBM382174 US10273244, Example 5::US10584135, Example 5

SMILES Cc1ncoc1-c1nnc(SCCCN2C[C@@H]3CCN([C@@H]3C2)c2ccc(cc2)C(F)(F)F)n1C

InChI Key InChIKey=GOLAHDQVVNCLCU-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 382174   

TargetD(3) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM382174(US10273244, Example 5 | US10584135, Example 5)
Affinity DataKi:  2.24nMAssay Description:3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
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TargetD(3) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM382174(US10273244, Example 5 | US10584135, Example 5)
Affinity DataKi:  2.24nMAssay Description:[3H]-Spiperone Binding Assay at hD3 and hD4 recombinant receptors CHO cells transiently transfected with human dopamine type 3 or 4 receptors (CHO-hD...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM382174(US10273244, Example 5 | US10584135, Example 5)
Affinity DataKi:  138nMAssay Description:Functional Calcium Assay at hD2 recombinant receptor. CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to G&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details
Go to US Patent

TargetD(2) dopamine receptor(Human)
Indivior

US Patent
LigandPNGBDBM382174(US10273244, Example 5 | US10584135, Example 5)
Affinity DataKi:  138nMAssay Description:CHO cells stably expressing human dopamine receptor type 2, long variant (hD2L), coupled to Gα16 protein (CHO-Gα16-hD2L) were seeded into b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2020
Entry Details
Go to US Patent