BDBM383716 US10280149, Example 198::[4-cyclobutyl-1-[[3-(trifluoromethyl)phenyl]methyl]piperazin-2-yl]-(6-methoxy-2-naphthyl)methanone

SMILES COc1ccc2cc(ccc2c1)C(=O)C1CN(CCN1Cc1cccc(c1)C(F)(F)F)C1CCC1

InChI Key InChIKey=HQJAIARQIASLOC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 383716   

TargetLysine-specific demethylase 2B(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 383716BDBM383716([4-cyclobutyl-1-[[3-(trifluoromethyl)phenyl]methyl...)
Affinity DataIC50: 302nMAssay Description:Full length KDM2B was cloned, expressed, and purified to homogeneity. Compound inhibition of KDM2B demethylase activity was assessed by monitoring th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
US Patent