BDBM384568 4-({cis or trans-4-[(3R or S)-3- (trifluoromethyl)piperidin- 1- yl]cyclohexyl}amino) quinazoline-6-carbonitrile::US9932350, 3-2

SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@H](N4CCCC(C(F)(F)F)C4)CC3)c2c1

InChI Key InChIKey=ALTVKDPSXAFXEM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 384568   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 384568BDBM384568(US9932350, 3-2 | 4-({cis or trans-4-[(3R or S)-3- ...)
Affinity DataIC50: 33nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2020
Entry Details
US Patent