BDBM386222 N-(cis-1-(cyclopropylcarbonyl)-2- (((1-(pyrimidin-2-yl)piperidin-4- yl)oxy)methyl)piperidin-3- yl)methanesulfonamide::US10287305, Example 196::US10508083, Example 196::US11292766, Example 196

SMILES CS(=O)(=O)N[C@H]1CCCN([C@H]1COC1CCN(CC1)c1ncccn1)C(=O)C1CC1

InChI Key InChIKey=DTFJIRXDIAQFEB-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 386222   

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386222(N-(cis-1-(cyclopropylcarbonyl)-2- (((1-(pyrimidin-...)
Affinity DataEC50:  30nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2022
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386222(N-(cis-1-(cyclopropylcarbonyl)-2- (((1-(pyrimidin-...)
Affinity DataEC50:  30nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2020
Entry Details
Go to US Patent

TargetOrexin receptor type 2(Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM386222(N-(cis-1-(cyclopropylcarbonyl)-2- (((1-(pyrimidin-...)
Affinity DataEC50:  30nMAssay Description:Chinese hamster ovary (CHO) dhfr-cells forcibly expressing human orexin type 2 receptor (hOX2R) were seeded in each well of Black clear bottom plate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent