BDBM386262 (2S,4R)-N-(5'- acetyl-2'-chloro-2- fluorobiphenyl-3- yl)-1-(2-(3-acetyl- 5-(2- methylpyrimidin-5- yl)-1H-indazol-1- yl)acetyl)-4- fluoropyrrolidine-2- carboxamide::US10287301, Compound 192::US10822352, Comp No. 192

SMILES CC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccc(c2F)-c2cc(ccc2Cl)C(C)=O)c2ccc(cc12)-c1cnc(C)nc1

InChI Key InChIKey=ADZYZOYLENRZDN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 386262   

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM386262((2S,4R)-N-(5'- acetyl-2'-chloro-2- fluorobiphenyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
US Patent

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM386262((2S,4R)-N-(5'- acetyl-2'-chloro-2- fluorobiphenyl-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent