BDBM386266 1-(2-((2S,4R)-4- fluoro-2-(2- hydroxypyridin-3- ylcarbamoyl) pyrrolidin-1-yl)-2- oxoethyl)-5- (pyridazin-4-yl)- 1H-indazole-3- carboxamide::US10287301, Compound 196::US10822352, Comp No. 196

SMILES NC(=O)c1nn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cccnc2O)c2ccc(cc12)-c1ccnnc1

InChI Key InChIKey=JRLHRYSCYBFYSG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 386266   

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM386266(1-(2-((2S,4R)-4- fluoro-2-(2- hydroxypyridin-3- yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
Go to US Patent

TargetComplement factor D(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM386266(1-(2-((2S,4R)-4- fluoro-2-(2- hydroxypyridin-3- yl...)
Affinity DataIC50: 1.00E+4nMAssay Description:Human Factor D (purified from human serum, Complement Technology, Inc.) at 80 nM final concentration was incubated with test compound at various conc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2020
Entry Details
Go to US Patent