BDBM337661 US10227295, Compound TSA::US11207431, TSA::US9751832, TSA::US9956192, Compound TSA

SMILES ONC(=O)CCCCCC(=O)Nc1ccccc1

InChI Key InChIKey=XCELUDLGZVVNON-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 337661   

TargetHistone deacetylase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 5nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 1.20nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/11/2019
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 5nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 1.20nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetHistone deacetylase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 5nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetHistone deacetylase 6(Human)
H. Lee Moffitt Cancer Center and Research Institute

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 1.20nMAssay Description:HDAC inhibition assays were performed by Reaction Biology Corp. (Malvern, Pa.) using isolated human, recombinant full-length HDAC1 and -6 from a bacu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
US Patent

TargetHistone deacetylase 4(Human)
The General Hospital

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 2.90E+3nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetHistone deacetylase 5(Human)
The General Hospital

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 1.70E+3nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetHistone deacetylase 7(Human)
The General Hospital

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 1.60E+3nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetHistone deacetylase 8(Human)
The General Hospital

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 546nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetHistone deacetylase 9(Human)
The General Hospital

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 3.80E+3nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent

TargetHistone deacetylase 11(Human)
The General Hospital

US Patent
LigandPNGBDBM337661(US9956192, Compound TSA | US9751832, TSA | US10227...)
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2022
Entry Details
US Patent