BDBM391204 US9957264, Example 5-275::tert-butyl (3R,4R)-4- (cyanomethyl)-3-fluoro-4-(3- {[4-(1-methoxyethyl)phenyl] amino}-4-oxo-4,5-dihydro- 1H-pyrazolo[4,3-c]pyridin-1- yl)piperidine-1-carboxylate (from I-7-2B, as a mixture of ether diastereomers)

SMILES COC(c1ccc(Nc2nn(c3cc[nH]c(=O)c23)[C@@]2(CC#N)CCN(C[C@H]2F)C(=O)OC(C)(C)C)cc1)C(F)(F)F

InChI Key InChIKey=FNPKYQXNXFNZBN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391204   

TargetTyrosine-protein kinase JAK2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391204(US9957264, Example 5-275 | tert-butyl (3R,4R)-4- (...)
Affinity DataIC50: 0.0900nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM391204(US9957264, Example 5-275 | tert-butyl (3R,4R)-4- (...)
Affinity DataIC50: 0.170nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2020
Entry Details
Go to US Patent