BDBM391883 US10301253, Example 33::methyl 4-((4-(((2',3'- dihydrospiro[cyclopropane- 1,1'-inden]-2- yl)amino)methyl)piperidin- 1-yl)methyl)benzoate

SMILES COC(=O)c1ccc(CN2CCC(CNC3CC33CCc4ccccc34)CC2)cc1

InChI Key InChIKey=QXIPWXPAJMSVSD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 391883   

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391883(US10301253, Example 33 | methyl 4-((4-(((2',3'- di...)
Affinity DataIC50: 12.2nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetLysine-specific histone demethylase 1A(Human)
Genentech

US Patent
LigandPNGBDBM391883(US10301253, Example 33 | methyl 4-((4-(((2',3'- di...)
Affinity DataIC50: 14.8nMAssay Description:LSD1 demethylase reactions were carried out in 50 mM HEPES pH 7.4, 100 mM NaCl, 1 mM DTT, 0.01% Tween-20, and 0.1 mg/mL BSA. All enzymatic reactions ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent