BDBM392212 US10301272, Example 100/12::US10301272, Example 100/9

SMILES CC(C)(C)NS(=O)(=O)c1ccc(-c2oc(nc2CC2CCCCC2)C(=O)N2CC3(C2)CCS(=O)(=O)CC3)c2ccccc12

InChI Key InChIKey=JGSCGNUMQKXWTL-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 392212   

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Phenex Pharmaceuticals

US Patent
LigandPNGBDBM392212(US10301272, Example 100/12 | US10301272, Example 1...)
Affinity DataIC50: 3.16nMAssay Description:Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Phenex Pharmaceuticals

US Patent
LigandPNGBDBM392212(US10301272, Example 100/12 | US10301272, Example 1...)
Affinity DataIC50: 3.16nMAssay Description:Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Phenex Pharmaceuticals

US Patent
LigandPNGBDBM392212(US10301272, Example 100/12 | US10301272, Example 1...)
Affinity DataIC50: 501nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding to RORγ was performed as follows: DNA encodin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Phenex Pharmaceuticals

US Patent
LigandPNGBDBM392212(US10301272, Example 100/12 | US10301272, Example 1...)
Affinity DataIC50: 794nMAssay Description:Cells were incubated for additional 16 h before renilla (REN) luciferase activities were measured sequentially in the same cell extract using a Dual-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Phenex Pharmaceuticals

US Patent
LigandPNGBDBM392212(US10301272, Example 100/12 | US10301272, Example 1...)
Affinity DataIC50: 1.26E+3nMAssay Description:Cells were incubated for additional 16 h before firefly (FF) luciferase activities were measured sequentially in the same cell extract using a Dual-L...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Phenex Pharmaceuticals

US Patent
LigandPNGBDBM392212(US10301272, Example 100/12 | US10301272, Example 1...)
Affinity DataIC50: 1.58E+4nMAssay Description:Determination of a ligand mediated Gal4 promoter driven transactivation to quantify ligand binding to RORγ was performed as follows: DNA encodin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent