BDBM393844 US10597367, Example 132::US9969726, Example 132

SMILES CONC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccoc1

InChI Key InChIKey=QCRTZAGVYPLDOL-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 393844   

TargetMetabotropic glutamate receptor 3(Rat)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393844(US9969726, Example 132 | US10597367, Example 132)
Affinity DataEC50:  2.93E+3nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Rat)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM393844(US9969726, Example 132 | US10597367, Example 132)
Affinity DataEC50:  2.93E+3nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 3(Rat)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393844(US9969726, Example 132 | US10597367, Example 132)
Affinity DataEC50:  5.26E+3nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 5(Rat)
Sanford Burnham Prebys Medical Discovery Institute

US Patent
LigandPNGBDBM393844(US9969726, Example 132 | US10597367, Example 132)
Affinity DataEC50:  5.26E+3nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Rat)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393844(US9969726, Example 132 | US10597367, Example 132)
Affinity DataEC50:  7.10E+3nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Rat)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393844(US9969726, Example 132 | US10597367, Example 132)
Affinity DataEC50:  7.10E+3nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Rat)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393844(US9969726, Example 132 | US10597367, Example 132)
Affinity DataEC50: >1.00E+4nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
Go to US Patent

TargetMetabotropic glutamate receptor 2(Rat)
Sanford-Burnham Medical Research Institute

US Patent
LigandPNGBDBM393844(US9969726, Example 132 | US10597367, Example 132)
Affinity DataEC50: >1.00E+4nMAssay Description:Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2020
Entry Details
Go to US Patent