BDBM393909 US9969749, Example 1-3::US9969749, Example 1-6::cis or trans-N,N- dimethyl-N''-[6-(pyridin- 4-yl)quinazolin-4- yl]cyclohexane-1,4- diamine

SMILES CN(C)C1CCC(CC1)Nc1ncnc2ccc(cc12)-c1ccncc1

InChI Key InChIKey=VLDGQMFRFLVRGT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 393909   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 393909BDBM393909(US9969749, Example 1-3 | cis or trans-N,N- dimethy...)
Affinity DataIC50: 11nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 393909BDBM393909(US9969749, Example 1-3 | cis or trans-N,N- dimethy...)
Affinity DataIC50: 2.29E+3nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent