BDBM393938 US9969749, Example 1-31::methyl 5-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}quinazolin-6- yl)pyridine-3- carboxylate

SMILES COC(=O)c1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1

InChI Key InChIKey=WSVQIDZNTHEDEH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 393938   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandChemical structure of BindingDB Monomer ID 393938BDBM393938(US9969749, Example 1-31 | methyl 5-(4-{[trans-4- (...)
Affinity DataIC50: 45nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2020
Entry Details
US Patent