BDBM394210 US9975876, 35::methyl 2-methoxy-6-({(3R,6R)-6- methyl-1-[(2-pyrimidin-2- ylphenyl)carbonyl]piperidin-3- yl}oxy)benzoate

SMILES COC(=O)c1c(OC)cccc1O[C@@H]1CC[C@@H](C)N(C1)C(=O)c1ccccc1-c1ncccn1

InChI Key InChIKey=YWOYASQIABQMBZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 394210   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394210(US9975876, 35 | methyl 2-methoxy-6-({(3R,6R)-6- me...)
Affinity DataIC50: 35nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM394210(US9975876, 35 | methyl 2-methoxy-6-({(3R,6R)-6- me...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2020
Entry Details
Go to US Patent