BDBM402050 N-(2-((4,6-dimethylpyrimidin-2- yl)(methyl)amino)ethyl)-N-ethyl-2- phenylnicotinamide::US10011595, B-9

SMILES CCN(CCN(C)c1nc(C)cc(C)n1)C(=O)c1cccnc1-c1ccccc1

InChI Key InChIKey=SHGGFVGQUGZZDM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402050   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402050(US10011595, B-9 | N-(2-((4,6-dimethylpyrimidin-2- ...)
Affinity DataIC50: 26.4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402050(US10011595, B-9 | N-(2-((4,6-dimethylpyrimidin-2- ...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
Go to US Patent