BDBM402145 N-ethyl-N-[2-[[4-(1-hydroxy- 1-methyl-ethyl)pyrimidin-2- yl]-methyl-amino]ethyl]-3- (triazol-2-yl)pyridine-2- carboxamide::US10011595, H-34

SMILES CCN(CCN(C)c1nccc(n1)C(C)(C)O)C(=O)c1ncccc1-n1nccn1

InChI Key InChIKey=UFGVWLQKOFBMJL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 402145   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402145(US10011595, H-34 | N-ethyl-N-[2-[[4-(1-hydroxy- 1-...)
Affinity DataIC50: 43nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent

TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402145(US10011595, H-34 | N-ethyl-N-[2-[[4-(1-hydroxy- 1-...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/26/2020
Entry Details
US Patent