BDBM402714 N-[1-(1-methylethyl)- 3-(trifluoromethyl)- 1H-pyrazol-4-yl]-5- piperazin-1- ylpyrazolo[1,5- a]pyrimidine-3- carboxamide trifluoroacetate::US10329294, Example 298

SMILES CC(C)n1cc(NC(=O)c2cnn3ccc(nc23)N2CCNCC2)c(n1)C(F)(F)F

InChI Key InChIKey=WYQFHPGDGMKDRT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 402714   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM402714(US10329294, Example 298 | N-[1-(1-methylethyl)- 3-...)
Affinity DataIC50: 17nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
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Date in BDB:
5/31/2020
Entry Details
US Patent