BDBM404049 US10336717, Compound 341

SMILES COC1CCC2(Cc3ccc(OCC4CC4)cc3C22N=C(SCC(F)(F)F)N(CC(F)(F)F)C2=O)CC1

InChI Key InChIKey=KJFIUHZBWOAFQC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 404049   

TargetBeta-secretase 1(Human)
Vitae Pharmaceuticals

US Patent
LigandPNGBDBM404049(US10336717, Compound 341)
Affinity DataIC50: 13.5nMAssay Description:For each compound being tested, the BACE activity was monitored in a fluorescence quenching assay (FRET) using the ectodomain of BACE (aa 1-454) fuse...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
US Patent