BDBM406916 4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-N-[(1S,2S)-2-hydroxycyclopentyl]pyridine-3-carboxamide::US10336761, Example 199

SMILES O[C@H]1CCC[C@@H]1NC(=O)c1cnccc1Nc1nc(nn2cccc12)-c1cccc(n1)C(F)F

InChI Key InChIKey=CZNZBPUYVZWCFL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 406916   

TargetTGF-beta receptor type-1(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406916(4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-...)
Affinity DataIC50: 61nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTGF-beta receptor type-2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM406916(4-({2-[6-(difluoromethyl)pyridin-2-yl]pyrrolo[2,1-...)
Affinity DataIC50: 1.50E+4nMAssay Description:Assays are conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGFβR1 T204D or HIS-TGFβR2 WT, anti-HIS detec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent