BDBM407247 6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-((1R,3R)- 3-hydroxycyclopentyl)- 4-(isopropylamino) nicotinamide::US10336762, Compound 188

SMILES CC(C)Nc1cc(ncc1C(=O)N[C@@H]1CCC(O)C1)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=XFGFAJSTBHXIAZ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407247   

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407247(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-((1R,3R...)
Affinity DataEC50:  275nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407247(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-((1R,3R...)
Affinity DataIC50: 8nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent