BDBM407248 6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-((1S,3S)- 3-hydroxycyclopentyl)- 4-(isopropylamino) nicotinamide::US10336762, Compound 189

SMILES CC(C)Nc1cc(ncc1C(=O)NC1CC[C@H](O)C1)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=XFGFAJSTBHXIAZ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407248   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407248(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-((1S,3S...)
Affinity DataIC50: 6nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
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TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407248(6-(3-cyanopyrrolo[1,2-b] pyridazin-7-yl)-N-((1S,3S...)
Affinity DataEC50:  136nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent