BDBM407333 6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N- methyl-4-(((1r,4r)-4- (2,2,2-trifluoroacetamido) cyclohexyl)amino) nicotinamide::US10336762, Compound 275

SMILES CNC(=O)c1cnc(cc1NC1CC[C@@H](CC1)NC(=O)C(F)(F)F)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=DQFHDTWYNXUUCQ-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407333   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407333(6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N- methyl...)
Affinity DataIC50: 3nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetTumor necrosis factor(Human)
Gilead Sciences

US Patent
LigandPNGBDBM407333(6-(3-cyanopyrrolo[1,2- b]pyridazin-7-yl)-N- methyl...)
Affinity DataEC50:  154nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (Gibco 200 mM L-alanyl-L-glutamine) (10 mM HEPES, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent