BDBM407612 US10336762, Compound 554::tert-butyl (3-(6-(3-cyano- pyrrolo[1,2-b]pyridazin- 7-yl)-4-(isopropylamino) nicotinamido)-2,2- difluoropropyl)carbamate

SMILES CC(C)Nc1cc(ncc1C(=O)NCC(F)(F)CNC(=O)OC(C)(C)C)-c1ccc2cc(cnn12)C#N

InChI Key InChIKey=SQFJLHBNGXWRDH-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 407612   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407612(US10336762, Compound 554 | tert-butyl (3-(6-(3-cya...)
Affinity DataIC50:  35nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTumor necrosis factor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM407612(US10336762, Compound 554 | tert-butyl (3-(6-(3-cya...)
Affinity DataEC50:  439nMAssay Description:Cryopreserved human monocytes (Stem Cell Technologies) were thawed, diluted in RPMI with GlutaMAX (GibcoŽ 200 mM L-alanyl-L-glutamine) (10 mM HEPES, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent