BDBM408044 US10336774, Example 12a::US10336774, Example 13a

SMILES N[C@H]1CC[C@@]11CCN(C1)c1cnc(Sc2cccc(Cl)c2Cl)c(N)n1

InChI Key InChIKey=JYGYLIUCXQRLRL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 408044   

LigandPNGBDBM408044(US10336774, Example 13a | US10336774, Example 12a)
Affinity DataIC50: 354nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM408044(US10336774, Example 13a | US10336774, Example 12a)
Affinity DataIC50: 5.79E+3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent