BDBM408735 US10358436, Example A149

SMILES COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(-c4cccc(C(=O)N5CCN(C)CC5)c4)n[nH]c3c1)C(=O)N2

InChI Key InChIKey=QNONTSBMPYWZDM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 408735   

TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 408735BDBM408735(US10358436, Example A149)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase A(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 408735BDBM408735(US10358436, Example A149)
Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetAurora kinase B(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 408735BDBM408735(US10358436, Example A149)
Affinity DataIC50: 1.00E+3nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University Health Network

US Patent
LigandChemical structure of BindingDB Monomer ID 408735BDBM408735(US10358436, Example A149)
Affinity DataIC50: 1.00E+3nMAssay Description:PLK3 inhibition was determined using the Z-Lyte assay kit from Invitrogen (cat #PV3802). The assay was performed using the recommended manufacturer&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent