BDBM411570 (R)-1-((2-(6-chloro-1H- pyrrolo[2,3-b]pyridin-4- yl)-6-(3-methyl- morpholino)pyrimidin-4- yl)imino)tetrahydro-1H- 1lambda6-thiophene 1-oxide::US10392376, Example 121::US10800769, Example 121::US11434233, Example 121

SMILES C[C@@H]1COCCN1c1cc(N=S2(=O)CCCC2)nc(n1)-c1cc(Cl)nc2[nH]ccc12

InChI Key InChIKey=YOGLHAZMOPMLKA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 411570   

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411570(US10392376, Example 121 | (R)-1-((2-(6-chloro-1H- ...)
Affinity DataIC50: 24nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411570(US10392376, Example 121 | (R)-1-((2-(6-chloro-1H- ...)
Affinity DataIC50: 24nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
University Of Texas

US Patent
LigandPNGBDBM411570(US10392376, Example 121 | (R)-1-((2-(6-chloro-1H- ...)
Affinity DataIC50: 133nMAssay Description:Inhibitors of ATR kinase are effective at inhibiting the ATR-driven phosphorylation of the downstream target Chk1 kinase at Serine 345, following the...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetATR-interacting protein/Serine/threonine-protein kinase ATR(Human)
University Of Texas

US Patent
LigandPNGBDBM411570(US10392376, Example 121 | (R)-1-((2-(6-chloro-1H- ...)
Affinity DataIC50: 24nMAssay Description:Human full-length FLAG-TEV-ATR and His6-ATRIP were co-expressed in HEK293 cells. The cell pellet (20 g) was harvested and lysed in 100 mL of lysis bu...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/13/2022
Entry Details
US Patent