BDBM412136 US10392402, Compound A::US10738007, Compound A::US10807966, Compound A::US11555039, Compound ID A

SMILES Cc1c[nH]c2nccc(Oc3c(F)cc(Nc4cc(Cl)nc(N)n4)cc3F)c12

InChI Key InChIKey=NRSGWEVTVGZDFC-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 412136   

TargetRho-associated protein kinase 1(Human)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
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In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human ROCK1More data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
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Date in BDB:
4/22/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
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Date in BDB:
4/19/2024
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
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In Depth
Date in BDB:
TBA
Entry Details
TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 2.80nMAssay Description:n general, kinases regulate many important cellular activities including cell growth, signaling, metabolism, etc. Different kinases have distinct fun...More data for this Ligand-Target Pair
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Date in BDB:
3/12/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 2.80nMMore data for this Ligand-Target Pair
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Date in BDB:
6/11/2021
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 2.80nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
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Date in BDB:
4/4/2021
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 2.80nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

TargetRho-associated protein kinase 2(Human)
Amakem Therapeutics

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 3nMAssay Description:Inhibition of His-tagged human ROCK2 expressed in Sf9 cells pre-incubated for 10 mins before S6 peptide substrate addition in presence of [33P]ATP an...More data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
TargetRho-associated protein kinase 1(Human)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 3.30nMAssay Description:n general, kinases regulate many important cellular activities including cell growth, signaling, metabolism, etc. Different kinases have distinct fun...More data for this Ligand-Target Pair
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In Depth
Date in BDB:
3/12/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 3.30nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
6/11/2021
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 3.30nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetRho-associated protein kinase 1(Human)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 3.30nMAssay Description:The following assay protocol is for measuring the phosphorylation of a peptide substrate (FAM-KKLRRTLSVA-OH wherein FAM is carboxyfluorescein). The p...More data for this Ligand-Target Pair
Ligand InfoPurchaseSimilars
In Depth
Date in BDB:
7/20/2020
Entry Details
US Patent

LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 252nMAssay Description:Inhibition of human TrkAMore data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 303nMAssay Description:Inhibition of human FLT3More data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human c-RAFMore data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human CDK7More data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human AXLMore data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
TargetAurora kinase A(Human)TBA
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human aurora AMore data for this Ligand-Target Pair
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In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human TrkBMore data for this Ligand-Target Pair
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In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human MST2More data for this Ligand-Target Pair
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In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human METMore data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human FMSMore data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PKBgammaMore data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PKBbetaMore data for this Ligand-Target Pair
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In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PKBalphaMore data for this Ligand-Target Pair
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In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PKAMore data for this Ligand-Target Pair
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In Depth
Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human ALKMore data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of ZIP (unknown origin)More data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of L-type calcium channel (unknown origin)More data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details
LigandPNGBDBM412136(US10392402, Compound A | US10738007, Compound A | ...)
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of MYLK (unknown origin)More data for this Ligand-Target Pair
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Date in BDB:
TBA
Entry Details