BDBM412793 US10399989, Example 9::US10611766, Example 9

SMILES COc1cc(Cl)ccc1C(=O)NCc1ccc(cc1)-c1nn(C2CCCC2)c2ncnc(N)c12

InChI Key InChIKey=TVMLHCWUWADBEV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 412793   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Loxo Oncology

US Patent
LigandPNGBDBM412793(US10399989, Example 9 | US10611766, Example 9)
Affinity DataIC50:  550nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Loxo Oncology

US Patent
LigandPNGBDBM412793(US10399989, Example 9 | US10611766, Example 9)
Affinity DataIC50: >1.00E+4nMAssay Description:EGFR binding affinity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5 nM Recombinant EGFR, var...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Loxo Oncology

US Patent
LigandPNGBDBM412793(US10399989, Example 9 | US10611766, Example 9)
Affinity DataIC50:  550nMAssay Description:BTKWT binding affinity of each compound tested was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Loxo Oncology

US Patent
LigandPNGBDBM412793(US10399989, Example 9 | US10611766, Example 9)
Affinity DataIC50: >1.00E+4nMAssay Description:EGFR binding affinity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. 2.5 nM Recombinant EGFR, var...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent