BDBM413085 6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl)-N-((1s,2s)-2-methylcyclopropyl)nicotinamide::US10407409, Example 169

SMILES C[C@H]1C[C@@H]1NC(=O)c1ccc(nc1)-n1ncc(c1O)-c1ccc(cc1)C#N

InChI Key InChIKey=KAEVQXUEEYMRCU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 413085   

TargetEgl nine homolog 1 [181-417](Human)
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413085(6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl)-N-...)
Affinity DataIC50: 60.3nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
7/27/2020
Entry Details
US Patent