BDBM414502 Methyl 2-(ethyl{2-[4-(1- hydroxy-1-methylethyl)-5- methyl-1,3-oxazol-2- yl]ethyl}carbamoyl)benzoate::US10435398, Example 16

SMILES CCN(CCc1nc(c(C)o1)C(C)(C)O)C(=O)c1ccccc1C(=O)OC

InChI Key InChIKey=YEOIUAOVKUYCCN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 414502   

TargetOrexin receptor type 2(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414502(Methyl 2-(ethyl{2-[4-(1- hydroxy-1-methylethyl)-5-...)
Affinity DataIC50: 630nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
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TargetOrexin/Hypocretin receptor type 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM414502(Methyl 2-(ethyl{2-[4-(1- hydroxy-1-methylethyl)-5-...)
Affinity DataIC50: 1.00E+4nMAssay Description:In a typical experiment the OX1 and OX2 receptor antagonistic activity of the compounds of the present invention was determined in accordance with th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
Go to US Patent