BDBM415557 US10428104, Example 88

SMILES c1cc(c(cc1[C@H]([C@@H]2[C@H]([C@H]([C@@H](O2)n3ccc4c3ncnc4N)O)O)O)F)Cl

InChI Key InChIKey=GTCYWLXMJRCJNE-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 415557   

TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataKi:  0.0200nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataIC50: 1nMAssay Description:Compounds were solubilized in DMSO and serially diluted, using 3-fold dilutions, into 100% DMSO at a concentration 50-fold greater than the desired a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetProtein arginine N-methyltransferase 5(Human)
Prelude Therapeutics

Curated by ChEMBL
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataIC50: 1nMAssay Description:Inhibition of PRMT5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PRMT5/MEP50 (unknown origin) using H4 peptide as substrate incubated for 25 mins in presence of [3H]-SAM by liquid scintillation counte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM415557(US10428104, Example 88)
Affinity DataKd:  241nMAssay Description:Binding affinity to N-terminal 6xHis-tagged full length human PRMT5/MEP50 expressed in sf21 cells using S-Adenosyl-L-methionine as substrate assessed...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed